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The first step in p53-mediated transcription is the binding of the protein to its recognition site in DNA. The degradation of p53 is as mentioned associated with MDM-2 binding. Biomolecules Free Full Text P53 S Extended Reach The Mutant P53 Secretome Html Describe starting from transcription to translation to activation ending with function how this protein s shape and function could come out different abnormal after a change in p53 DNA sequence. . However mutant p53s often dont induce MDM-2 and are thus able to accumulate at very high concentrations. The more defective the mutation the greater the risk. After various types of genotoxic insults p53 is stabilized translocates to the nucleus and binds as a dimer of dimers to its response element RE McLure and Lee 1998. P53 mutations can cause expression of abnormal proteins or result in complete absence of P53 expression. This aids in the suppression of cancer or tumors and ...

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